-1-methyl-1H-benzo[d]imidazol-2-yl)

Name	Bendamustine
Synonyms	Bendamustine 4-(5-(Bis(2-chloroethyl) -1-methyl-1H-benzo[d]imidazol-2-yl) 5-(Bis(2-chloroethyl)amino)-1-methyl-2-benzimidazolebutyric acid 5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazole-2-butanoic acid 1H-BenziMidazole-2-butanoicacid, 5-[bis(2-chloroethyl)aMino]-1-Methyl- 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid 4-{5-[Bis(2-chloroethyl)amino]-1-methyl-1H-benzimidazol-2-yl}butanoic acid 4-(5-(bis(2-chloroethyl)aMino)-1-Methyl-1H-benzo[d]iMidazol-2-yl)butanoic acid
CAS	16506-27-7
InChI	InChI=1/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)

Molecular Formula	C16H21Cl2N3O2
Molar Mass	358.26
Density	1.31±0.1 g/cm3(Predicted)
Boling Point	585.2±50.0 °C(Predicted)
Flash Point	307.7°C
Vapor Presure	1.55E-14mmHg at 25°C
pKa	4.50±0.10(Predicted)
Storage Condition	2-8°C
Refractive Index	1.599
In vitro study	Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe. Bendamustine reduces the viability of multiple myeloma (MM) cell lines, such as RPMI-8226 and 8226-LR5 cells, with IC 25 s of 101.8 μM and 585.5 μM after 24 h incubation, and 51.7 and 374.3 μM after 48 h incubation, respectively. Bendamustine induces a specific caspase-dependent MM cell death and inhibits the spindle-assembly checkpoint.
In vivo study	Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model.

biological activity	Bendamustine (SDX105) is a nitrogen mustard drug used to treat chronic lymphocytic leukemia, multiple myeloma and non-Hodgkin's lymphoma.
target	DNA Alkylator/Crosslinker
toxic substance data	information provided by: pubchem.ncbi.nlm.nih.gov (external link)

Last Update：2024-04-09 15:16:48

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CAS: 16506-27-7
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